Endocrine Abstracts

Introduction: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that arises from the parafollicular C-cells of the thyroid gland with a tendency to regional and distant metastases. It is a rare tumor, making up about 3% of all thyroid malignancies. MTC occurs in both heritable and sporadic forms, early diagnosis is important as it can improve treatment outcomes. We report a case of metastatic medullary thyroid cancer with both diagnostic and therapeutic challenges. <...

Introduction: Pituitary adenomas are a rare condition in children and young people. The prolactinoma represents the most frequent of them. We report a case of an atypically evolution of aggressive macroprolactinoma in young patient.Case: It’s about a boy of 14 years old with previous history of headache from 5 years without visual disturbance. He was admitted for intracranial hypertension syndrome. In clinical examination no dysmorphic syndrome, a g...

Introduction: Clinically non-secreting pituitary adenomas are rare in children We report a case of a silent somatotropic adenoma revealed by anatomopathology.Case: A 13 year-old patient with no prior history of sudden onset intracranial hypertension syndrome. Clinical examination showed no dysmorphic Syndrome, no galactorrhea, no delay or statutory advance, Tanner P1S3. The MRI reveals a heterogeneous tumor process intra and suprasellar of 30 mm *15 mm o...

Introduction: Pituitary adenomas are rare in infants and adolescents. Prolactinomas account for 50% of these pituitary adenomas. In adolescent girls, it is usually a microprolactinoma revealed by puberty delay or amenorrhea. We report a rare case of a macroprolactinoma in an adolescent girl revealed by visual impairment.Case presentation: A 15-year-old adolescent girl presented with loss of vision over a long period of time. Magnetic resonance imaging re...

Introduction: McCune-Albright syndrome (MAS) is a rare, Mosaic genetic (Lethal in the homozygous state) but non-hereditary disorder. The diagnosis is most often made in childhood, the management is multidisciplinary and includes several aspects. We report a case of Mc Cune Albright syndrome and the various difficulties encountered in its management.Case report: A, H 22 years old, at the age of 6 months presented skin macules. At the age of 3 years he dev...

Introducing: Hypothyroidism is the most common endocrinopathy causing rhabdomyolysis. Muscle manifestations are common in hypothyroidism, but myopathy is most often limited to discrete clinical signs such as myalgias, stiffness or cramps accompanied by a simple elevation of muscle enzymes. On the other hand, rhabdomyolysis associated with hypothyroidism is a rare diagnosis to our knowledge. We report a case of severe rhabdomyolysis in the setting of profound Hashimoto’s h...

Graves’ disease is a rare and severe disease that most often affects older children and is predominantly female. The diagnosis is made in the presence of a clinical picture very suggestive of thyrotoxicosis, confirmed by biological and radiological tests. We present the case of an 11-year-old female patient who presented with a moderate presented of basedow with an ultrasound appearance of thyroiditis for which scintigraphy was helpful in the diagnosis. Female patient, 11...

Introduction: Hypothyroidism is the most common endocrine dysfunction during pregnancy. In pregnancy, hypothyroidism is most often due to chronic autoimmune thyroiditis (Hashimoto’s disease) The consequences of hypothyroidism vary depending on the time of onset of hypothyroidism during pregnancy and the etiology retroplacental hematoma is a serious complication of hypothyroidism We report the case of a patient with in utero fetal death on retroplacental hematoma complicat...

Introduction: The association of multi-organ autoimmune disorders is described. We report a case of Hashimoto’s thyroiditis (HT) and primary biliary cholangitis (PBC), both are a chronic autoimmune inflammation, with lymphocytic infiltration and destruction of thyroid cells for (HT) and progressive destruction of intrahepatic bile ducts leading to cirrhosis for (PBC)Case report: 54-year-old female patient, followed for (PBC) at cirrhosis stage admit...

Introduction: Liver function abnormalities in hyperthyroidism are common, several abnormalities have been reported: hepatic cytolysis, cholestasis, insufficiency or even non-specific abnormalities. The pathophysiology of hepatic dysfunction secondary to hyperthyroidism is not yet well established. Graves’ disease can be associated with various autoimmune diseases. However, association with Primary biliary cirrhosis has been described in few cases in literature. We report ...